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Capsaicin
Brand Name(s):
Axsain, Zostrix
Drug Class:
Analgesic
Available OTC?: Yes
Available Generic?: Yes
Available In
Why Prescribed
How It Works
Range and Frequency
Onset of Effect
Duration of Action
Dietary Advice
Storage
Missed Dose
Stopping the Drug
Prolonged Use
Over 60
Driving and Hazardous Work
Alcohol
Pregnancy
Breast Feeding
Infants and Children
Special Concerns
Overdose Symptoms
What to Do
Drug Interactions
Food Interactions
Disease Interactions


Available In
Cream

Why Prescribed
To relieve neuralgia--pain in the nerve endings near the surface of the skin. Capsaicin is commonly prescribed for neuralgia associated with shingles, an acutely painful condition caused by infection with the varicella zoster virus, the same organism that causes chicken pox. Capsaicin is also used to relieve mild to moderate arthritis, Diabetic neuropathy (pain caused by nerve cell damage that occurs as a complication of diabetes), and postoperative pain.

How It Works
When applied topically, capsaicin (a derivative of hot peppers) appears to reduce the amount of a natural chemical known as substance P, which is present in painful joints. Substance P is believed to be involved in two processes central to arthritis: the release of enzymes that produce Inflammation and the transmission of pain impulses from the joints to the central nervous system. By blocking the production and release of substance P, capsaicin can reduce the pain associated with arthritis as well as dampen the transmission of pain messages to the brain.

Range and Frequency
Apply a small amount to the affected area up to 4 times a day. Do not apply to broken or irritated skin. If the use of a bandage is recommended, do not apply it too tightly.

Onset of Effect
Therapeutic pain response is usually achieved in 1 to 2 weeks but may take as long as 4 weeks.

Duration of Action
Up to 6 hours.

Dietary Advice
This medication can be used without regard to diet.

Storage
Store in a tightly sealed container away from heat and direct light.

Missed Dose
Apply it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.

Stopping the Drug
Pain relief will last only as long as capsaicin is used regularly. If you discontinue using the medication and the pain returns, it is safe to resume treatment.

Prolonged Use
No special problems are expected. Burning and stinging sensations upon application frequently subside with prolonged use. If your condition worsens or does not improve after 1 month, discontinue using capsaicin and consult your doctor.

Over 60
No special problems are expected.

Driving and Hazardous Work
No problems are expected.

Alcohol
No special precautions are necessary.

Pregnancy
No problems have been reported.

Breast Feeding
No problems are expected.

Infants and Children
Not recommended for use on children under the age of 2. No problems are expected in older children.

Special Concerns
You may not be able to use capsaicin if you are allergic to it or if you have ever had an allergic reaction to hot peppers. Wash your hands thoroughly after applying the cream; if you are using it for arthritis of the hands, wait 30 minutes before washing. It can cause a burning sensation if even small amounts get into the eyes or on other sensitive areas of the body. If you wear contact lenses, be especially cautious. If it does get into your eyes, flush them with water. On other sensitive areas of the body, wash the area with warm (but not hot) soapy water. After applying capsaicin cream, avoid contact with children and pets until you have thoroughly washed your hands.

Overdose Symptoms
No cases of overdose have been reported.

What to Do
An overdose is unlikely to be life-threatening. However, if someone applies a much larger dose than prescribed, suffers adverse side effects, or accidentally ingests it, call your doctor or the nearest poison control center for advice.

Drug Interactions
Capsaicin may alter the action of some drugs or trigger unwanted side effects. Consult your doctor about any other drugs that you take, including over-the-counter medications.

Food Interactions
None are known.

Disease Interactions
Consult your doctor if you have broken or irritated skin, or conditions that may result in broken skin, on the area to be treated.


Date Published: 4/14/2005
Date Reviewed: 4/14/2005


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Serious

No serious side effects are associated with the use of capsaicin.
Common

Stinging or burning sensation when cream is applied. This should subside with regular use, as your body adjusts to the medication.
Less Common

Skin redness; coughing, sneezing, or shortness of breath if dried residues of the drug are inhaled.
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