What Is It?
Health Benefits

Dosage Information

Guidelines for Use

General Interaction
Possible Side Effects
Evidence Based Rating Scale


What Is It?

Along with the bold yet delicate taste that shiitake, maitake, and reishi mushrooms add to soups and other dishes, these gourmet delicacies are prized as herbal medicines. Traditional Asian healers have used them for centuries to strengthen the immune system and promote longevity. Recently, an Extract from a different mushroom altogether—PSK, from the Coriolus (Coriolus versicolor) mushroom --was identified as a possible ally in the fight against cancer. While mushrooms other than these may well have specific health-promoting actions, they haven't been as thoroughly researched for medicinal purposes.

Shiitake (Lentinus edodes) mushrooms are low in calories and are a good source of potassium, phosphorous, iron, selenium, Protein, Vitamin D2 (ergosterol, a plant sterol that is converted to vitamin D when exposed to ultra-violet rays), thiamin, riboflavin, and niacin, as well as all essential amino acids, enzymes, fiber, and nucleic acid derivatives. In ancient China, herbalists utilized shiitake for a host of ailments including colds, flu, headaches, measles, gastrointestinal distress, and liver problems, as well as for improving circulation and increasing vitality. Ancient physicians prescribed shiitake to boost chi, or life energy. Now, shiitake are a subject of intense research, and the medicinal capabilities attributed to the shiitake mushroom are so prized that it is now among the most cultivated of the world’s edible mushrooms.

Maitake (Grifola frondosa) mushrooms are also packed with nutrients and have long been used in traditional Chinese medicine. They are rich in minerals such as calcium, magnesium and potassium, vitamins B and D2, and niacin, as well as amino acids and fiber. Maitake mushrooms contain a protein-bound polysaccharide compound called beta-glucan, which has been identified as an active constituent responsible for its immunity-enhancing, anti-tumor properties.

Reishi (Ganoderma lucidum) mushrooms also contain beta-glucans and are one of the few known sources of another polysaccharaide group called triterpenes, which are also thought to have potential immunomodulating, anti-tumor, and antioxidant activities. Reishi varieties also contain vitamins including D2, minerals, and unsaturated fatty acids. Reishi mushrooms have also been touted for immunity-enhancing and regulating activities.

The Coriolus versicolor mushroom contains one of the most-studied mushroom extracts. Since the early 1970s, more than 400 studies have evaluated the extract, PSK (polysaccharide krestin), for its anti-cancer properties. Another polysaccharide found in the Coriolus mushroom, called PSP (polysaccharide peptide), also appears to have cancer-fighting properties. And, like Maitake, PSK extract is high in immune-boosting beta-glucan.

Another medicinal mushroom, the cordyceps species, also contains immune-boosting beta-glucans and triterpenes. The cordyceps grows out of caterpillar larvae in the Himalayas, and has been used in traditional Chinese medicine to treat cough and wheezing and to reduce fatigue and calm nervousness. Although the cordyceps species has been touted for its potential to enhance physical performance, scientific evidence does not support these claims.  

Health Benefits

All of these healing mushrooms contain polysaccharides, powerful compounds that help in building immunity. Polysaccharides and other compounds in mushrooms may also lower cholesterol, reduce the risk of dangerous blood clots, prevent heart disease, treat diabetes, relieve bronchitis and sinusitis, and possibly fight cancer cells and increase the potency of cancer treatments.

Specifically, mushrooms may help to:

Improve risk factors for heart disease, such as lowering blood pressure and cholesterol. Shiitake and maitake mushrooms contain polysaccharides called lentinan, which may have potential cardio-protective effects, such as cholesterol lowering properties; and other polysaccharides found in reishi and a variety of other mushrooms also may have additional cardio-protective benefits. Several studies in animals have shown the potential of these mushrooms for improving blood pressure and cholesterol levels. For example, in a 1987 study done with rats with high blood pressure, those fed a diet containing shiitake and maitake mushroom powder for nine weeks experienced a decrease in blood pressure and cholesterol levels while no differences in cholesterol levels were seen in control groups. However, the cholesterol decrease was seen in HLD-cholesterol (“good” cholesterol) and triglycerides, and the mushrooms did not seem to affect LDL-cholesterol (“bad” cholesterol) levels in the rats. (1) In a similar experiment in 1989, hypertensive rats fed maitake mushrooms for eight weeks experienced a significant reduction in blood pressure but no changes in cholesterol levels compared to control groups; and those fed shiitake mushrooms for eight weeks showed significantly lower cholesterol levels but no change in blood pressure compared to the control group. (2) A 1996 study compared the levels of cholesterol, phospholipids, and triglycerides in cholesterol-fed rats with or without fortification with 20% maitake mushroom powder. In the maitake-fed rats lipid levels were consistently lower, and the weights of extirpated liver and fat pads were significantly less. Researchers concluded the maitake mushroom powder appears to alter lipid metabolism by inhibiting the accumulation of liver lipids and the elevation of serum lipids, but further research is needed to determine whether the effect is the same in humans. (3) Another animal study in 2001 found rats fed maitake, shiitake or enokitake mushroom fiber for four weeks showed lowered serum total cholesterol, higher fecal cholesterol excretion, and improved LDL (“bad” cholesterol) levels compared to the control group. (4) Other mushrooms, such as the oyster mushroom (Pleurotus ostreatus), have also been the subject of studies that indicate cholesterol lowering effects in animals. However, studies are needed to determine the efficacy of medicinal mushrooms for lowering cholesterol and blood pressure in humans.


Treat diabetes. The fruiting bodies of maitake mushrooms contain polysaccharides that appear to have a hypoglycemic effect, possibly by activating insulin receptors, which may be beneficial in regulating type 2 diabetes. Preliminary clinical evidence indicates maitake mushroom extracts may help to reduce symptoms of type 2 diabetes, including reducing blood sugar levels. In a 2001 study, diabetic rats and control groups were fed diets containing either 20% maitake or control diets for 100 days. After 10 weeks, fasting glucose levels were significantly lower and insulin levels were significantly higher in the group fed maitake compared to the control diet alone. (5) And in a 2002 study of insulin-resistant mice, a water-soluble extract of maitake mushroom (FXM) was shown to be as effective as the conventional diabetic medication glipizide. (6) A 2007 study in humans had similar findings when testing oyster mushrooms. In the six-month study, 89 diabetic patients included oyster mushrooms in their diets for 21-day periods (7 days with mushrooms, 7 days without mushrooms, 7 days with mushrooms—the quantity of mushrooms was not described). Blood pressure levels, plasma glucose levels, and other factors were measured at the start of the study and after each 7-day period. Eating oyster mushrooms seemed to reduce systolic and diastolic blood pressure, as well as significantly lowering blood glucose levels. These levels increased when mushroom was withdrawn and decreased again after restarting eating mushrooms. (7) Also in 2007 in Taiwan, a randomized, double-blind, placebo-controlled study evaluating the efficacy of an extract of Agaricus mushroom (Agaricus blazei Murill) found that using the extract in conjunction with the conventional medications metformin and glipizide was more efficacious than conventional medications alone. In the study, 72 diabetic patients aged 20 to 75 who had diabetes for more than one year and had been treated with the conventional medications for more than six months were enrolled and randomized to receive either mushroom extract or placebo daily for 12 weeks. At the end of the study, the group receiving mushroom extract showed significant improvement in insulin resistance compared to the control group, and there was a 20% increase in plasma concentration of the glucose-regulating hormone adiponectin in the treatment group compared to a 12% decrease in the control group. (8)


Fight cancer.  The immunomodulating effects of medicinal mushrooms have been touted for their ability to strengthen the immune system during cancer treatment, improve survival rates and inhibit the spread of the disease. The Coriolus mushroom has shown particular promise in combating breast, lung, stomach and colon cancers; the maitake mushroom and cordyceps mushroom also have shown positive anti-tumor activity. PSK extract has been used as an adjunct to chemotherapy to improve response and survival rate in cancer patients. Hundreds of studies, most of which have been in Japan, have demonstrated this potential use of medicinal mushrooms and their extracts. A 1993 study showed that when PSK was combined with conventional surgery and radiation for lung cancer patients, those receiving the PSK extract had a 5-year survival rate of 39% for stages 1 and 2 and 22% survival rate for stage 3, compared to survival rates of 16% for stages 1 and 2 and 5% for stage 3 without the PSK. (9) A 1997 study found that when used as an adjunct to cancer therapy, PSP seems to improve immune function by increasing white cell, natural killer cell, and antibody levels. (10) A 1998 review of studies evaluating PSP to treat cancer, patients with esophageal, gastric, and lung cancers taking PSP while also undergoing radiotherapy or chemotherapy concluded that PSP helped to alleviate side effect symptoms and prevent decline in immune status. (11) A 2000 review of the Japanese studies of PSP and PSK done since the 1970s found PSP significantly improved quality of life, pain relief and enhanced immune status in 70% to 97% of patients with stomach, esophagus, lung, ovary and cervical cancers. The review also found that PSK and PSP boosted immune cell production, ameliorated chemotherapy symptoms, and enhanced natural killer cell production and function. (12) However, a 2008 review of the immunomodulating effects of mushrooms indicates the majority of studies evaluating the beneficial effects of mushrooms have been of low quality and lack standardization. The researchers claim no scientific basis exists for the use of mushrooms or mushroom extracts in the treatment of human patients, but say there is significant potential for higher-quality studies to understand the potential of mushrooms to treat humans. (13)


Preliminary research indicates the beta-glucan found in maitake mushrooms also has anti-tumor activity. The research suggests that maitake mushrooms can prevent metastasis of experimentally induced tumors as well as prevent tumor occurrence in normal cells. (14-16) The immune-enhancing and anti-tumor properties of cordyceps and reishi mushrooms, which are likely due to the beta-glucan and triterpene polysaccharides, also are studied for their potential to treat cancer. Studies in animals with cancer have shown that cordyceps mushrooms improve immune response, reduce tumor size and lengthen survival time. (17-20) A preliminary study in 36 patients with advanced-stage cancers found that taking cordyceps orally after chemotherapy treatment for cancer may improve quality of life and cellular immunity. (21) A 2003 study found that a specific reishi mushroom polysaccharide extract, Ganopoloy, stimulates immune function in advanced cancer patients. In the study, 34 patients with advanced-stage cancers took 1,800 mg of Ganopoly three times a day before meals for 12 weeks. Patients in the treatment group showed increases in interleukin-2 (IL-2), IL-6, interferon-gamma, and natural killer cell activity. However, there was a concommitant decrease in IL-1 and tumor necrosis factor-alpha. (22) A 2005 review of studies indicates reishi mushrooms seem to inhibit proliferation of several human cancer cell lines in the laboratory, including, lung, liver, breast, prostate, cervix, and bladder, as well as lymphocytic leukemia. These extracts also seem to have direct cytotoxic activity against human breast, liver and cervical tumor cells, mouse sarcoma. (23) Further high-quality research is needed to establish safety and efficacy in humans.


Relieve viral infections, such as common colds, flu, bronchitis and sinusitis. A 2004 review of the beneficial effects of edible mushrooms found the immune-enhancing properties of mushrooms help to protect against cold, flu, and infections by inhibiting viral replication. However, research is lacking in this area. Studies are needed to determine the potential use of mushrooms and their extracts to treat viral infections. (24)


  • Capsule
  • Extract
  • Food
  • Powder
  • Tablet
  • Tea
  • Tincture

Dosage Information

Agaricus: For diabetes, 500 mg of Agaricus mushroom extract taken three times daily has been used. For preventing chemotherapy side effects, an unspecified dose of agaricus mushroom extract three times daily for six weeks has been used.

Cordyceps: A typical dosage of cordyceps is 2 to 3 grams dried powder daily.

Maitake: 20% maitake powder diet has been used.

PSK: A typical dose of PSK tea is prepared from 20 grams of dried coriolus fruiting bodies three times daily, or take capsules containing up to 5 g per day of the dried fruiting bodies. As an adjuvant to cancer chemotherapy, 3 g of PSK daily has been used. 

Reishi: Traditionally, taken orally, 1.5 to 9 g of the crude dried mushroom daily, 1 to 1.5 g daily of reishi powder, or 1mL daily of reishi tincture has been used. 

Shiitake: 8 g daily of shiitake mushroom extract has been used for up to six months.

Guidelines for Use

Don't gather mushrooms in the wild yourself. Edible varieties can easily be mistaken for deadly ones.

 General Interaction

Because compounds in reishi supplements can delay blood clotting, consult your doctor before trying them if you are on long-term aspirin therapy or take other anticoagulant medications. The combination may raise the risk of unwanted bleeding.

Note: For information on interactions with specific generic drugs, see our WholeHealthMD Drug/Nutrient Interactions Chart.

Possible Side Effects

Shiitake, maitake, reishi, cordyceps and PSK mushrooms are all safe to take at appropriate doses. Agaricus mushrooms also seem to be well tolerated. PSK in particular appears to be free of adverse side effects according to clinical tests of cancer patients. Allergic reactions to mushrooms, although seldom reported, are possible.


  • If you are pregnant or breast-feeding, talk with your doctor before using mushrooms therapeutically.

  • In rare cases, taking reishi mushrooms daily for periods of three to six months can cause dryness in the mouth, itchiness and skin rashes, nose bleeds, stomach upset, or bloody stools. If you experience any of these side effects, stop taking reishi mushroom preparations


1. Kabir, Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo). 1987 Oct;33(5):341-6.
2. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo). 1989 Feb;35(1):91-4.
3. Kubo K, Nanba H. The effect of maitake mushrooms on liver and serum lipids. Altern Ther Health Med. 1996 Sep;2(5):62-6.
4. Fukushima M, Ohashi T, Fujiwara Y, et al. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Exp Biol Med (Maywood). 2001 Sep;226(8):758-65.
5. Horio H, Ohtsuru M. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. J Nutr Sci Vitaminol (Tokyo). 2001 Feb;47(1):57-63.
6. Manohar V, Talpur NA, Echard BW, et al. Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice. Diabetes Obes Metab. 2002 Jan;4(1):43-8.
7. Khatun K, Mahtab H, Khanam PA, et al. Oyster mushroom reduced blood glucose and cholesterol in diabetic subjects. Mymensingh Med J. 2007 Jan;16(1):94-9.
8. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102.
9. Hayakawa K, Mitsuhashi N, Saito Y, et al. Effect of krestin (PSK) as adjuvant treatment after radical radiotherapy in patients with non-small cell lung cancer. Anticancer Res. 1993;13:1815-1820.
10. Qian ZM, Xu MF, Tang PL. Polysaccharide peptide (PSP) restores immunosuppression induced by cyclophosphamide in rats. Am J Chin Med. 1997;25:27-35.
11. Ng TB. A review of research on the protein-bound polysaccharide (polysaccharopeptiede, PSP) from the mushroom Coriolus versicolor (Basidiomycetees: Polyporaceae). Gen Pharmacol. 1998 Jan;30(1):1-4.
12. Kidd PM. The use of mushroom glucans and proteoglycans in cancer treatment. Altern Med Rev. 2000 Feb;5(1):4-27.
13. Borchers AT, Krishnamurthy A, Keen CL, et al. Immunobiology of mushrooms. Exp Biol Med (Maywood). 2008 Mar;233(3):259-76.
14. Adachi K, Nanba H, Kuroda H. Potentiation of host-mediated antitumor activity in mice by beta-glucan obtained from Grifola frondosa (maitake). Chem Pharm Bull (Tokyo). 1987;35:262-70.
15. Nanba H, Kubo K. Effect of Maitake D-fraction on cancer prevention. Ann NY Acad Sci. 1997;833:204-7.
16. Nanba H. Activity of maitake D-fraction to inhibit carcinogenesis and metastasis. Ann NY Acad Sci. 1995;768:243-5.
17. Yoshida J, Takamura S, Yamaguchi N, et al. Cordyceps sinensis (CordyMax Cs-4) supplementation does not improve endurance exercise performance. Int J Sport Nutr Exerc metab. 2004;114:236-42.
18. Yamaguchi N, Yoshida J, Ren LJ, et al. Augmentation of various immune reactivities of tumor-bearing hosts with an extract of Cordyceps sinensis. Biotherapy. 1990;2:199-205.
19. Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English). 1991;104:4-8.
20. Chiu JH, Ju CH, Wu LH, et al. Cordyceps sinensis increases the expression of major histocompatibility complex class II antigens on human hepatoma cell line HA22T/VGH cells. Am J Chin Med. 1998;26:159-70.
21. Zhou DH, Lin LZ. [Effect of Jinshuibao capsule on the immunological function of 36 patients with advanced cancer.] [Article in Chinese]. Chung Kuo Chung His I Chieh Ho Tsa Chih. 1995;15:476-8.
22. Gao Y, Zhou S, Jiang W, et al. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest. 2003;32:201-15.
23. Yuen JW, Gohel MD. Anticancer effects of Ganoderma lucidum: a review of scientific evidence. Nutr Cancer. 2005;53:11-7.
24. Rajewska J, Balasinska B. [Biologically active compounds of edible mushrooms and their beneficial impact on health.] Postepy Hig Med Dosw (Online). 2004;58:352-7.

Evidence Based Rating Scale  

The Evidence Based Rating Scale is a tool that helps consumers translate the findings of medical research studies with what our clinical advisors have found to be efficacious in their personal practice. This tool is meant to simplify which supplements and therapies demonstrate promise in the treatment of certain conditions. This scale does not take into account any possible interactions with any medication/ condition/ or therapy which you may be currently undertaking. It is therefore advisable to ask your doctor before starting any new treatment regimen.









Date Published: 04/19/2005

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